Phakellistatins: An Underwater Unsolved Puzzle

نویسندگان

  • Alessandra Meli
  • Consiglia Tedesco
  • Giorgio Della Sala
  • Rosaria Schettini
  • Fernando Albericio
  • Francesco De Riccardis
  • Irene Izzo
چکیده

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.

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عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2017